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Using CC(C)(C)OC(=O)N1CCC(COC(COS(C)(=O)=O)c2cc(Cl)cc3cn(COCC[Si](C)(C)C)nc23)(c2ccc(F)cc2)CC1, [C-]#N to produce CC(C)(C)OC(=O)N1CCC(COC(CC#N)c2cc(Cl)cc3cn(COCC[Si](C)(C)C)nc23)(c2ccc(F)cc2)CC1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCOC(C)=O, CN(C)C=O
Using CC(C)(C)OC(=O)N1CCC(COC(COS(C)(=O)=O)c2cc(Cl)cc3cn(COCC[Si](C)(C)C)nc23)(c2ccc(F)cc2)CC1, [C-]#N to produce CC(C)(C)OC(=O)N1CCC(COC(CC#N)c2cc(Cl)cc3cn(COCC[Si](C)(C)C)nc23)(c2ccc(F)cc2)CC1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCOC(C)=O, CN(C)C=O
Using O=C1c2ccccc2C(=O)N1Cc1ccc(Cl)nc1 to produce NCc1ccc(Cl)nc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCO, O
Using O=C1c2ccccc2C(=O)N1Cc1ccc(Cl)nc1 to produce NCc1ccc(Cl)nc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCO, O
Using C[O-], Brc1cncc(Br)c1 to produce COc1cncc(Br)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O
Using C[O-], Brc1cncc(Br)c1 to produce COc1cncc(Br)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O
Using Oc1ccc(-c2nccs2)cc1, CCBr to produce CCOc1ccc(-c2nccs2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CC(C)=O
Using Oc1ccc(-c2nccs2)cc1, CCBr to produce CCOc1ccc(-c2nccs2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CC(C)=O
Using N#CCCl, O=C(c1ccccc1)c1ccc(O)c(Cl)c1Cl to produce N#CCOc1ccc(C(=O)c2ccccc2)c(Cl)c1Cl, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CC(C)=O
Using N#CCCl, O=C(c1ccccc1)c1ccc(O)c(Cl)c1Cl to produce N#CCOc1ccc(C(=O)c2ccccc2)c(Cl)c1Cl, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CC(C)=O
Using O=C1CCCC(=O)O1 to produce O=C(O)CCCC(=O)O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
c1ccccc1, CCN(CC)CC
Using O=C1CCCC(=O)O1 to produce O=C(O)CCCC(=O)O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
c1ccccc1, CCN(CC)CC
Using CC1(C)CC(=O)c2cc(O)c(O)cc2O1, BrCCBr to produce CC1(C)CC(=O)c2cc3c(cc2O1)OCCO3, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCC(C)=O
Using CC1(C)CC(=O)c2cc(O)c(O)cc2O1, BrCCBr to produce CC1(C)CC(=O)c2cc3c(cc2O1)OCCO3, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCC(C)=O
Using CCOC(=O)CBr, CC(C)(C)OC(=O)N1C(=O)CCc2ccc(OCc3cccc(Cl)c3)cc21 to produce CCOC(=O)CC1Cc2ccc(OCc3cccc(Cl)c3)cc2N(C(=O)OC(C)(C)C)C1=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using CCOC(=O)CBr, CC(C)(C)OC(=O)N1C(=O)CCc2ccc(OCc3cccc(Cl)c3)cc21 to produce CCOC(=O)CC1Cc2ccc(OCc3cccc(Cl)c3)cc2N(C(=O)OC(C)(C)C)C1=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)OCC[C@@H]12 to produce C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)OCC[C@@H]12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, CC(C)=O
Using C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)OCC[C@@H]12 to produce C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@]2(C)OCC[C@@H]12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, CC(C)=O
Using COC(=O)[C@H](C)Nc1c(C)cccc1C to produce Cc1cccc(C)c1N[C@@H](C)C(=O)O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CO
Using COC(=O)[C@H](C)Nc1c(C)cccc1C to produce Cc1cccc(C)c1N[C@@H](C)C(=O)O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CO
Using Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3Br)n(-c3ccccc3)c(=O)c12, OB(O)c1ccc2cc[nH]c2c1 to produce Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3ccc4cc[nH]c4c3)n(-c3ccccc3)c(=O)c12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1COCCO1, CCOC(C)=O
Using Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3Br)n(-c3ccccc3)c(=O)c12, OB(O)c1ccc2cc[nH]c2c1 to produce Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3ccc4cc[nH]c4c3)n(-c3ccccc3)c(=O)c12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1COCCO1, CCOC(C)=O
Using COc1cc(CCc2cc(N)[nH]n2)cc(OC)c1, COC(=O)c1cnc(N2CCN3CCCC3C2)nc1 to produce COc1cc(CCc2cc(NC(=O)c3cnc(N4CCN5CCCC5C4)nc3)[nH]n2)cc(OC)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
Cc1ccccc1
Using COc1cc(CCc2cc(N)[nH]n2)cc(OC)c1, COC(=O)c1cnc(N2CCN3CCCC3C2)nc1 to produce COc1cc(CCc2cc(NC(=O)c3cnc(N4CCN5CCCC5C4)nc3)[nH]n2)cc(OC)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
Cc1ccccc1
Using Cc1cnc(Nc2ccc(OCC(O)CN(C)C)cc2)nc1-n1ccc2ccccc21, CN(C)CC(O)COc1ccc(Nc2nccc(N3CCc4ccccc43)n2)cc1 to produce CN(C)CC(O)COc1ccc(Nc2cc(N3CCc4ccccc43)ncn2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN1CCCC1=O
Using Cc1cnc(Nc2ccc(OCC(O)CN(C)C)cc2)nc1-n1ccc2ccccc21, CN(C)CC(O)COc1ccc(Nc2nccc(N3CCc4ccccc43)n2)cc1 to produce CN(C)CC(O)COc1ccc(Nc2cc(N3CCc4ccccc43)ncn2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN1CCCC1=O
Using CCOC(=O)c1c(-c2cccc(F)c2)noc1C(C)C to produce CC(C)c1onc(-c2cccc(F)c2)c1C(=O)O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, C1CCOC1
Using CCOC(=O)c1c(-c2cccc(F)c2)noc1C(C)C to produce CC(C)c1onc(-c2cccc(F)c2)c1C(=O)O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, C1CCOC1
Using CN(C)C=O, CC(=O)NCc1ccc2[nH]ccc2c1 to produce CC(=O)NCc1ccc2[nH]cc(C=O)c2c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, O=P(Cl)(Cl)Cl
Using CN(C)C=O, CC(=O)NCc1ccc2[nH]ccc2c1 to produce CC(=O)NCc1ccc2[nH]cc(C=O)c2c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, O=P(Cl)(Cl)Cl
Using CN1CC(=Cc2ccccc2)C(=O)C(=Cc2ccccc2)C1, NNCC(F)(F)F to produce CN1CC(=Cc2ccccc2)C2=NN(CC(F)(F)F)C(c3ccccc3)C2C1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CO
Using CN1CC(=Cc2ccccc2)C(=O)C(=Cc2ccccc2)C1, NNCC(F)(F)F to produce CN1CC(=Cc2ccccc2)C2=NN(CC(F)(F)F)C(c3ccccc3)C2C1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CO
Using COC(=O)C1CC(=O)N(c2ccc(OCc3ccc(F)c(F)c3)cc2)C1 to produce O=C1CC(CO)CN1c1ccc(OCc2ccc(F)c(F)c2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, C1CCOC1
Using COC(=O)C1CC(=O)N(c2ccc(OCc3ccc(F)c(F)c3)cc2)C1 to produce O=C1CC(CO)CN1c1ccc(OCc2ccc(F)c(F)c2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, C1CCOC1
Using CNC1CCOc2cc(CN3CCCCC3)ccc21, O=C(O)CC(NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 to produce CN(C(=O)CC(NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)C1CCOc2cc(CN3CCCCC3)ccc21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O, ClCCl
Using CNC1CCOc2cc(CN3CCCCC3)ccc21, O=C(O)CC(NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 to produce CN(C(=O)CC(NS(=O)(=O)c1cccc(C(F)(F)F)c1)c1ccccc1)C1CCOc2cc(CN3CCCCC3)ccc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O, ClCCl
Using COC(=O)C(C)=NNC(=S)NCc1cc(F)ccc1Cl to produce Cc1n[nH]c(=S)n(Cc2cc(F)ccc2Cl)c1=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CO
Using COC(=O)C(C)=NNC(=S)NCc1cc(F)ccc1Cl to produce Cc1n[nH]c(=S)n(Cc2cc(F)ccc2Cl)c1=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CO
Using C[C@@H](NC(=O)[C@H](CCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)c1ccc(O)cc1 to produce C[C@@H](NC(=O)[C@@H](N)CCCNC(=O)OCc1ccccc1)c1ccc(O)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCOC(C)=O
Using C[C@@H](NC(=O)[C@H](CCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)c1ccc(O)cc1 to produce C[C@@H](NC(=O)[C@@H](N)CCCNC(=O)OCc1ccccc1)c1ccc(O)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCOC(C)=O
Using CCOC(=O)C=Cc1ccc(O)cn1 to produce CCOC(=O)CCc1ccc(O)cn1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCO
Using CCOC(=O)C=Cc1ccc(O)cn1 to produce CCOC(=O)CCc1ccc(O)cn1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCO
Using CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc([N+](=O)[O-])c(S(C)(=O)=O)c3)S(C)(=O)=O)c(C3CC3)cc12 to produce CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(N)c(S(C)(=O)=O)c3)S(C)(=O)=O)c(C3CC3)cc12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCOC(C)=O, CCO
Using CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc([N+](=O)[O-])c(S(C)(=O)=O)c3)S(C)(=O)=O)c(C3CC3)cc12 to produce CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(c3ccc(N)c(S(C)(=O)=O)c3)S(C)(=O)=O)c(C3CC3)cc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCOC(C)=O, CCO
Using CN(CCCO)C(=O)OC(C)(C)C to produce CN(CCC=O)C(=O)OC(C)(C)C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
ClCCl
Using CN(CCCO)C(=O)OC(C)(C)C to produce CN(CCC=O)C(=O)OC(C)(C)C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
ClCCl
Using CSCCN(C)C(C)SC, Nc1ccc2c(c1)[C@@H](NC(=O)c1ccc(-c3ccccc3F)cc1F)[C@H](O)C2 to produce CSCCN(C)C(C)=Nc1ccc2c(c1)[C@@H](NC(=O)c1ccc(-c3ccccc3F)cc1F)[C@H](O)C2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
c1ccncc1
Using CSCCN(C)C(C)SC, Nc1ccc2c(c1)[C@@H](NC(=O)c1ccc(-c3ccccc3F)cc1F)[C@H](O)C2 to produce CSCCN(C)C(C)=Nc1ccc2c(c1)[C@@H](NC(=O)c1ccc(-c3ccccc3F)cc1F)[C@H](O)C2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
c1ccncc1
Using CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2F)cc2cnc(N(C)Cc3ccc(OC)cc3)cc21 to produce CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2F)cc2cnc(NC)cc21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O=C(O)C(F)(F)F
Using CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2F)cc2cnc(N(C)Cc3ccc(OC)cc3)cc21 to produce CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2F)cc2cnc(NC)cc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O=C(O)C(F)(F)F
Using II, CCCn1c(N)nc2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O to produce CCCn1c(I)nc2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using II, CCCn1c(N)nc2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O to produce CCCn1c(I)nc2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using O=Cc1ccc(OC(F)(F)F)cc1, COc1ccc(/C=C/C(C)=O)cc1 to produce COc1ccc(/C=C/C(=O)/C=C/c2ccc(OC(F)(F)F)cc2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCO, O
Using O=Cc1ccc(OC(F)(F)F)cc1, COc1ccc(/C=C/C(C)=O)cc1 to produce COc1ccc(/C=C/C(=O)/C=C/c2ccc(OC(F)(F)F)cc2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCO, O
Using OC1CCOC1, C[C@@H](NC(=O)Cc1ccc(O)cc1)c1ccc(NCC(F)(F)F)cn1 to produce C[C@@H](NC(=O)Cc1ccc(OC2CCOC2)cc1)c1ccc(NCC(F)(F)F)cn1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using OC1CCOC1, C[C@@H](NC(=O)Cc1ccc(O)cc1)c1ccc(NCC(F)(F)F)cn1 to produce C[C@@H](NC(=O)Cc1ccc(OC2CCOC2)cc1)c1ccc(NCC(F)(F)F)cn1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using CC1(C)CC(O)CC(C)(C)N1O, CCCCCCCCI to produce CCCCCCCCON1C(C)(C)CC(O)CC1(C)C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
Clc1ccccc1
Using CC1(C)CC(O)CC(C)(C)N1O, CCCCCCCCI to produce CCCCCCCCON1C(C)(C)CC(O)CC1(C)C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
Clc1ccccc1
Using CCOC(=O)c1cnc(N2CC(NC(=O)OC(C)(C)C)C2)nc1 to produce CCOC(=O)c1cnc(N2CC(N)C2)nc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1COCCO1
Using CCOC(=O)c1cnc(N2CC(NC(=O)OC(C)(C)C)C2)nc1 to produce CCOC(=O)c1cnc(N2CC(N)C2)nc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1COCCO1
Using CCOC(=O)COc1ccc(OC)c2occc12 to produce CCOC(=O)COc1ccc(O)c2occc12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, ClCCl
Using CCOC(=O)COc1ccc(OC)c2occc12 to produce CCOC(=O)COc1ccc(O)c2occc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, ClCCl
Using CCOC(=O)CC(C)N1CCC(Cc2ccccc2)CC1 to produce CC(CCO)N1CCC(Cc2ccccc2)CC1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using CCOC(=O)CC(C)N1CCC(Cc2ccccc2)CC1 to produce CC(CCO)N1CCC(Cc2ccccc2)CC1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using CC(C)(Br)C(=O)Br, c1ccc2c(c1)CCCC2 to produce CC1Cc2cc3c(cc2C1=O)CCCC3, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
ClCCl
Using CC(C)(Br)C(=O)Br, c1ccc2c(c1)CCCC2 to produce CC1Cc2cc3c(cc2C1=O)CCCC3, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
ClCCl
Using Cc1c(F)ccc(C(=O)O)c1F, O=Cc1nccs1 to produce Cc1c(F)c(C(=O)O)cc(C(O)c2nccs2)c1F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using Cc1c(F)ccc(C(=O)O)c1F, O=Cc1nccs1 to produce Cc1c(F)c(C(=O)O)cc(C(O)c2nccs2)c1F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using COC(=O)c1ccc(C(C)(C)C)c(C#N)c1 to produce CC(C)(C)c1ccc(C(=O)O)cc1C#N, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1COCCO1
Using COC(=O)c1ccc(C(C)(C)C)c(C#N)c1 to produce CC(C)(C)c1ccc(C(=O)O)cc1C#N, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1COCCO1
Using Brc1cc(Br)cc(OCC2CC2)c1, CCOC(=O)COc1ccc(S)cc1C to produce CCOC(=O)COc1ccc(Sc2cc(Br)cc(OCC3CC3)c2)cc1C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN1CCCC1=O, CCN(CC)CC
Using Brc1cc(Br)cc(OCC2CC2)c1, CCOC(=O)COc1ccc(S)cc1C to produce CCOC(=O)COc1ccc(Sc2cc(Br)cc(OCC3CC3)c2)cc1C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN1CCCC1=O, CCN(CC)CC
Using CCOC(=O)c1ccc(N)cc1, COc1cn(C(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N to produce CCOC(=O)c1ccc(NC(=O)C(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O
Using CCOC(=O)c1ccc(N)cc1, COc1cn(C(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C(=O)O)c(=O)cc1-c1cc(Cl)ccc1C#N to produce CCOC(=O)c1ccc(NC(=O)C(CCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)n2cc(OC)c(-c3cc(Cl)ccc3C#N)cc2=O)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O
Using O=C1Cc2ncc(C(F)(F)F)cc2CN1 to produce FC(F)(F)c1cnc2c(c1)CNCC2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using O=C1Cc2ncc(C(F)(F)F)cc2CN1 to produce FC(F)(F)c1cnc2c(c1)CNCC2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1
Using Cc1cnc(N)n1-c1ccc(B2OC(C)(C)C(C)(C)O2)cc1, C[C@H]1COCCN1c1nc(Cl)nc2c1CCN(C(=O)OC(C)(C)C)C2 to produce Cc1cnc(N)n1-c1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(C(=O)OC(C)(C)C)C3)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CC#N, O
Using Cc1cnc(N)n1-c1ccc(B2OC(C)(C)C(C)(C)O2)cc1, C[C@H]1COCCN1c1nc(Cl)nc2c1CCN(C(=O)OC(C)(C)C)C2 to produce Cc1cnc(N)n1-c1ccc(-c2nc3c(c(N4CCOC[C@@H]4C)n2)CCN(C(=O)OC(C)(C)C)C3)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CC#N, O
Using NCCCn1ccnc1, O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)O)ccn1 to produce O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)NCCCn2ccnc2)ccn1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O, CO
Using NCCCn1ccnc1, O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)O)ccn1 to produce O=C(COc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1cc(C(=O)NCCCn2ccnc2)ccn1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O, CO
Using CCOC(=O)[C@H]1CC(=O)O[C@@H]1C(=O)N(Cc1ccc2ccccc2c1)[C@H](C)[C@H](C/C=C/c1nc2ccccc2o1)c1ccc2c(c1)OCO2, [OH-] to produce CCOC(=O)[C@@H](CC(=O)[O-])[C@H](O)C(=O)N(Cc1ccc2ccccc2c1)[C@H](C)[C@H](C/C=C/c1nc2ccccc2o1)c1ccc2c(c1)OCO2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, C1CCOC1
Using CCOC(=O)[C@H]1CC(=O)O[C@@H]1C(=O)N(Cc1ccc2ccccc2c1)[C@H](C)[C@H](C/C=C/c1nc2ccccc2o1)c1ccc2c(c1)OCO2, [OH-] to produce CCOC(=O)[C@@H](CC(=O)[O-])[C@H](O)C(=O)N(Cc1ccc2ccccc2c1)[C@H](C)[C@H](C/C=C/c1nc2ccccc2o1)c1ccc2c(c1)OCO2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O, C1CCOC1
Using CCO, O=C([O-])c1ccccc1 to produce CCCCC#CC#CCOc1ccc(C(=O)O)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O
Using CCO, O=C([O-])c1ccccc1 to produce CCCCC#CC#CCOc1ccc(C(=O)O)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
O
Using NCC(=O)O, CCOC(=O)c1ncc2nc(-c3cncc(Br)c3)sc2c1O to produce O=C(O)CNC(=O)c1ncc2nc(-c3cncc(Br)c3)sc2c1O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CO
Using NCC(=O)O, CCOC(=O)c1ncc2nc(-c3cncc(Br)c3)sc2c1O to produce O=C(O)CNC(=O)c1ncc2nc(-c3cncc(Br)c3)sc2c1O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CO
Using COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccccc1)CC3 to produce COc1ccc2c3c(c(=O)oc2c1)CNCC3, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1, CO
Using COc1ccc2c3c(c(=O)oc2c1)CN(Cc1ccccc1)CC3 to produce COc1ccc2c3c(c(=O)oc2c1)CNCC3, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
C1CCOC1, CO
Using Nc1ncccc1C=O, COC(=O)CCCCCCC(C)=O to produce COC(=O)CCCCCCc1ccc2cccnc2n1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCO
Using Nc1ncccc1C=O, COC(=O)CCCCCCC(C)=O to produce COC(=O)CCCCCCc1ccc2cccnc2n1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCO
Using CC(O)Cc1cc2cccc3c2c(c1Br)NS3(=O)=O, OC(CBr)CBr to produce OC(CBr)CN1Sc2cccc3cccc1c23, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O
Using CC(O)Cc1cc2cccc3c2c(c1Br)NS3(=O)=O, OC(CBr)CBr to produce OC(CBr)CN1Sc2cccc3cccc1c23, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CN(C)C=O
Using O=C(O)COc1cccc(F)c1, NCC(O)CN1CCc2ccccc2C1 to produce O=C(COc1cccc(F)c1)NCC(O)CN1CCc2ccccc2C1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
ClCCl, CCN(C(C)C)C(C)C
Using O=C(O)COc1cccc(F)c1, NCC(O)CN1CCc2ccccc2C1 to produce O=C(COc1cccc(F)c1)NCC(O)CN1CCc2ccccc2C1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
ClCCl, CCN(C(C)C)C(C)C
Using COc1cccc2c1c1c(n2CCOCc2ccccc2)CCCC1C(=O)O to produce COc1cccc2c1c1c(n2CCO)CCCC1C(=O)O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCNCC, CO
Using COc1cccc2c1c1c(n2CCOCc2ccccc2)CCCC1C(=O)O to produce COc1cccc2c1c1c(n2CCO)CCCC1C(=O)O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CCNCC, CO
Using c1c[nH]cn1, Cn1c(=O)c2c(-c3cccc(F)c3)n3c(c2n(C)c1=O)C(c1ccc(Cl)o1)O[C@@H](COS(C)(=O)=O)C3 to produce Cn1c(=O)c2c(-c3cccc(F)c3)n3c(c2n(C)c1=O)[C@H](c1ccc(Cl)o1)O[C@@H](Cn1ccnc1)C3, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CC#N, O
Using c1c[nH]cn1, Cn1c(=O)c2c(-c3cccc(F)c3)n3c(c2n(C)c1=O)C(c1ccc(Cl)o1)O[C@@H](COS(C)(=O)=O)C3 to produce Cn1c(=O)c2c(-c3cccc(F)c3)n3c(c2n(C)c1=O)[C@H](c1ccc(Cl)o1)O[C@@H](Cn1ccnc1)C3, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
CC#N, O
Using CCOC(=O)C=CC(Cc1ccc(Cl)cc1)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 to produce CCOC(=O)CCC(Cc1ccc(Cl)cc1)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
Clc1ccccc1Cl, C1CCOC1
Using CCOC(=O)C=CC(Cc1ccc(Cl)cc1)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 to produce CCOC(=O)CCC(Cc1ccc(Cl)cc1)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.
Clc1ccccc1Cl, C1CCOC1