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Using Cc1nn(C(=O)OC(C)(C)C)c2ncccc12, O=C1CCC(=O)N1Br to produce BrCc1n[nH]c2ncccc12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | ClC(Cl)(Cl)Cl |
Using Cc1nn(C(=O)OC(C)(C)C)c2ncccc12, O=C1CCC(=O)N1Br to produce BrCc1n[nH]c2ncccc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | ClC(Cl)(Cl)Cl |
Using C1COCCO1, CC(O)C#CC1(C)C=CN=C(N)N1 to produce C#Cc1cc(C)nc(N)n1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | Cc1ccccc1 |
Using C1COCCO1, CC(O)C#CC1(C)C=CN=C(N)N1 to produce C#Cc1cc(C)nc(N)n1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | Cc1ccccc1 |
Using CN(Cc1c[nH]c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C, O=S(=O)(Cl)c1ccccn1 to produce CN(Cc1cn(S(=O)(=O)c2ccccn2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, C1CCOC1 |
Using CN(Cc1c[nH]c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C, O=S(=O)(Cl)c1ccccn1 to produce CN(Cc1cn(S(=O)(=O)c2ccccn2)c(-c2cccnc2F)c1F)C(=O)OC(C)(C)C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, C1CCOC1 |
Using [NH4+], CCCc1nc2cnc3cccnc3c2n1CCCC=NOC to produce CCCc1nc2c(N)nc3cccnc3c2n1CCCC=NOC, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | ClC(Cl)Cl |
Using [NH4+], CCCc1nc2cnc3cccnc3c2n1CCCC=NOC to produce CCCc1nc2c(N)nc3cccnc3c2n1CCCC=NOC, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | ClC(Cl)Cl |
Using OCCCSc1cccc(Br)c1, N#Cc1ccc(B(O)O)cc1 to produce N#Cc1ccccc1-c1ccc(SCCCO)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC#N, O |
Using OCCCSc1cccc(Br)c1, N#Cc1ccc(B(O)O)cc1 to produce N#Cc1ccccc1-c1ccc(SCCCO)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC#N, O |
Using O=C1CCOc2cc(Br)ccc21, NO to produce ON=C1CCOc2cc(Br)ccc21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, CCO |
Using O=C1CCOc2cc(Br)ccc21, NO to produce ON=C1CCOc2cc(Br)ccc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, CCO |
Using Clc1ccccn1, OB(O)c1ccccc1 to produce c1ccc(-c2ccccn2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | COCCOC |
Using Clc1ccccn1, OB(O)c1ccccc1 to produce c1ccc(-c2ccccn2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | COCCOC |
Using CC(C)(C)OC(=O)N(Cc1ccc(NC(=O)c2ccc(CN(Cc3ncc[nH]3)Cc3ncc[nH]3)cc2)cc1)Cc1ncc[nH]1 to produce O=C(Nc1ccc(CNCc2ncc[nH]2)cc1)c1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using CC(C)(C)OC(=O)N(Cc1ccc(NC(=O)c2ccc(CN(Cc3ncc[nH]3)Cc3ncc[nH]3)cc2)cc1)Cc1ncc[nH]1 to produce O=C(Nc1ccc(CNCc2ncc[nH]2)cc1)c1ccc(CN(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using CCN(CC)CCCC(C)N, O=C(Cl)c1ccnc2ccccc12 to produce CCN(CC)CCCC(C)NC(=O)c1ccnc2ccccc12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, CCN(CC)CC |
Using CCN(CC)CCCC(C)N, O=C(Cl)c1ccnc2ccccc12 to produce CCN(CC)CCCC(C)NC(=O)c1ccnc2ccccc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, CCN(CC)CC |
Using N#Cc1cc(F)cc(B(O)O)c1, CC1Nc2ccc(Br)cc2C(C)(c2ccccc2)O1 to produce C[C@@H]1Nc2ccc(-c3cc(F)cc(C#N)c3)cc2[C@](C)(c2ccccc2)O1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, COCCOC |
Using N#Cc1cc(F)cc(B(O)O)c1, CC1Nc2ccc(Br)cc2C(C)(c2ccccc2)O1 to produce C[C@@H]1Nc2ccc(-c3cc(F)cc(C#N)c3)cc2[C@](C)(c2ccccc2)O1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, COCCOC |
Using Nc1nc2cc([N+](=O)[O-])ccc2c2cccnc12, ClCCl to produce Nc1ccc2c(c1)nc(N)c1nc(Cl)ccc12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCO |
Using Nc1nc2cc([N+](=O)[O-])ccc2c2cccnc12, ClCCl to produce Nc1ccc2c(c1)nc(N)c1nc(Cl)ccc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCO |
Using COC(=O)C(=O)c1ccc(O)cc1, ClCC1CO1 to produce COC(=O)C(=O)c1ccc(OCC2CO2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O |
Using COC(=O)C(=O)c1ccc(O)cc1, ClCC1CO1 to produce COC(=O)C(=O)c1ccc(OCC2CO2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O |
Using O=[N+]([O-])c1ccc(F)cc1, Oc1ccccc1O to produce O=[N+]([O-])c1ccc(Oc2ccccc2O)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(=O)N(C)C |
Using O=[N+]([O-])c1ccc(F)cc1, Oc1ccccc1O to produce O=[N+]([O-])c1ccc(Oc2ccccc2O)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(=O)N(C)C |
Using Cc1cccc(-c2nc(Cl)cc(-c3cccnc3)n2)n1, NCCc1c[nH]c2ccccc12 to produce Cc1cccc(-c2nc(NCCc3c[nH]c4ccccc34)cc(-c3cccnc3)n2)n1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN1CCCC1=O |
Using Cc1cccc(-c2nc(Cl)cc(-c3cccnc3)n2)n1, NCCc1c[nH]c2ccccc12 to produce Cc1cccc(-c2nc(NCCc3c[nH]c4ccccc34)cc(-c3cccnc3)n2)n1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN1CCCC1=O |
Using [N-]=[N+]=NCC(O)COc1cccc(Cl)c1 to produce NCC(O)COc1cccc(Cl)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, C1CCOC1 |
Using [N-]=[N+]=NCC(O)COc1cccc(Cl)c1 to produce NCC(O)COc1cccc(Cl)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, C1CCOC1 |
Using O=Cc1cc(Cl)c(Cl)cc1F, COc1cc(F)ccc1O to produce COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, O |
Using O=Cc1cc(Cl)c(Cl)cc1F, COc1cc(F)ccc1O to produce COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, O |
Using CCC(=O)c1c(-c2ccc(C(=O)OC)cc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 to produce CCC(=O)c1c(-c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using CCC(=O)c1c(-c2ccc(C(=O)OC)cc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1 to produce CCC(=O)c1c(-c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2c(=O)n1Cc1ccc(S(C)(=O)=O)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using O=Cc1ccc(O)cc1, CC(C)(C)[Si](C)(C)Cl to produce CC(C)(C)[Si](C)(C)Oc1ccc(C=O)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCOC(C)=O, CN(C)C=O |
Using O=Cc1ccc(O)cc1, CC(C)(C)[Si](C)(C)Cl to produce CC(C)(C)[Si](C)(C)Oc1ccc(C=O)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCOC(C)=O, CN(C)C=O |
Using O=C(Cc1ccccc1)NC1CN(OC(=O)c2ccccc2)C1=O to produce O=C(Cc1ccccc1)NC1CN(O)C1=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using O=C(Cc1ccccc1)NC1CN(OC(=O)c2ccccc2)C1=O to produce O=C(Cc1ccccc1)NC1CN(O)C1=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using O=c1cc(Nc2ccc(I)cc2F)c([N+](=O)[O-])c[nH]1, CI to produce Cn1cc([N+](=O)[O-])c(Nc2ccc(I)cc2F)cc1=O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, O |
Using O=c1cc(Nc2ccc(I)cc2F)c([N+](=O)[O-])c[nH]1, CI to produce Cn1cc([N+](=O)[O-])c(Nc2ccc(I)cc2F)cc1=O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, O |
Using C[S-], COc1cc(F)c(F)cc1OC to produce COc1cc(SC)c(F)cc1O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O |
Using C[S-], COc1cc(F)c(F)cc1OC to produce COc1cc(SC)c(F)cc1O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O |
Using COCCOC, Cc1cc(N)c(F)cc1Br to produce Cc1cc(N)c(F)cc1C1=CCC2(CC1)OCCO2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using COCCOC, Cc1cc(N)c(F)cc1Br to produce Cc1cc(N)c(F)cc1C1=CCC2(CC1)OCCO2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using CCOC(=O)C1=C(NC(=O)c2ccc(OC(F)F)cc2)CCCC1 to produce CCOC(=O)[C@H]1CCCC[C@H]1NC(=O)c1ccc(OC(F)F)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using CCOC(=O)C1=C(NC(=O)c2ccc(OC(F)F)cc2)CCCC1 to produce CCOC(=O)[C@H]1CCCC[C@H]1NC(=O)c1ccc(OC(F)F)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1, O=C(c1ccccc1)c1ccccc1 to produce O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NC(c2ccccc2)c2ccccc2)C[C@H]1Cc1ccccc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(=O)O, Cc1ccccc1 |
Using N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1, O=C(c1ccccc1)c1ccccc1 to produce O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NC(c2ccccc2)c2ccccc2)C[C@H]1Cc1ccccc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(=O)O, Cc1ccccc1 |
Using COC(=O)C(C#N)c1cc(C)c(OC)cc1[N+](=O)[O-] to produce COc1cc([N+](=O)[O-])c(CC#N)cc1C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using COC(=O)C(C#N)c1cc(C)c(OC)cc1[N+](=O)[O-] to produce COc1cc([N+](=O)[O-])c(CC#N)cc1C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using O=C(C#Cc1ccccc1)Nc1ccccc1, COc1cc(CBr)cc(OC)c1OC to produce COc1cc(CN(C(=O)C#Cc2ccccc2)c2ccccc2)cc(OC)c1OC, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, O |
Using O=C(C#Cc1ccccc1)Nc1ccccc1, COc1cc(CBr)cc(OC)c1OC to produce COc1cc(CN(C(=O)C#Cc2ccccc2)c2ccccc2)cc(OC)c1OC, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, O |
Using CCCCCCCCCCCCCCOc1cc(C(=O)Cl)ccc1OC, CC(=O)NCc1ccccn1 to produce CCCCCCCCCCCCCCOc1cc(C(=O)N(Cc2ccccn2)C(C)=O)ccc1OC, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | C1CCOC1 |
Using CCCCCCCCCCCCCCOc1cc(C(=O)Cl)ccc1OC, CC(=O)NCc1ccccn1 to produce CCCCCCCCCCCCCCOc1cc(C(=O)N(Cc2ccccn2)C(C)=O)ccc1OC, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | C1CCOC1 |
Using CCOC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(C(F)(F)F)c3)(C(F)(F)F)C2)cc1C(F)(F)F to produce O=C(O)c1ccc(C2=NOC(c3cc(Cl)cc(C(F)(F)F)c3)(C(F)(F)F)C2)cc1C(F)(F)F, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, CO |
Using CCOC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(C(F)(F)F)c3)(C(F)(F)F)C2)cc1C(F)(F)F to produce O=C(O)c1ccc(C2=NOC(c3cc(Cl)cc(C(F)(F)F)c3)(C(F)(F)F)C2)cc1C(F)(F)F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O, CO |
Using NC(=O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H](O)[C@H]2O)c1 to produce NC(=O)C1=CN([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H](O)[C@H]2O)C=CC1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(C)O |
Using NC(=O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H](O)[C@H]2O)c1 to produce NC(=O)C1=CN([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](OP(=O)(O)O)[C@@H]3O)[C@@H](O)[C@H]2O)C=CC1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(C)O |
Using CCO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1N, CCc1[nH]c(C(=O)O)nc1Cl to produce CCO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | ClCCl, CC(=O)N(C)C |
Using CCO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1N, CCc1[nH]c(C(=O)O)nc1Cl to produce CCO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1NC(=O)c1nc(Cl)c(CC)[nH]1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | ClCCl, CC(=O)N(C)C |
Using COC(=O)c1ccc(CN(C)CC2CCCCN2)cc1, O=Cc1ccc(Oc2ccc(Br)cc2)cc1 to produce CN(Cc1ccc(C(=O)O)cc1)CC1CCCCN1Cc1ccc(Oc2ccc(Br)cc2)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(Cl)Cl, CCN(C(C)C)C(C)C |
Using COC(=O)c1ccc(CN(C)CC2CCCCN2)cc1, O=Cc1ccc(Oc2ccc(Br)cc2)cc1 to produce CN(Cc1ccc(C(=O)O)cc1)CC1CCCCN1Cc1ccc(Oc2ccc(Br)cc2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(Cl)Cl, CCN(C(C)C)C(C)C |
Using COC(=O)COc1ccc(OCC#Cc2cc(Br)cc(C#CCN3CCOCC3)c2)cc1C, C#Cc1ccc(Cl)cc1 to produce COC(=O)COc1ccc(OCC#Cc2cc(C#CCN3CCOCC3)cc(C#Cc3ccc(Cl)cc3)c2)cc1C, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, CCN(CC)CC |
Using COC(=O)COc1ccc(OCC#Cc2cc(Br)cc(C#CCN3CCOCC3)c2)cc1C, C#Cc1ccc(Cl)cc1 to produce COC(=O)COc1ccc(OCC#Cc2cc(C#CCN3CCOCC3)cc(C#Cc3ccc(Cl)cc3)c2)cc1C, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, CCN(CC)CC |
Using CCOC(=O)c1c(Cl)ccnc1Cl to produce OCc1c(Cl)ccnc1Cl, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | C1CCOC1 |
Using CCOC(=O)c1c(Cl)ccnc1Cl to produce OCc1c(Cl)ccnc1Cl, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | C1CCOC1 |
Using NCc1ccc2[nH]c(C(F)(F)F)cc2c1, CCOc1cccc(-c2ccc(C(=O)O)cn2)c1 to produce CCOc1cccc(-c2ccc(C(=O)NCc3ccc4[nH]c(C(F)(F)F)cc4c3)cn2)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, CCN(C(C)C)C(C)C |
Using NCc1ccc2[nH]c(C(F)(F)F)cc2c1, CCOc1cccc(-c2ccc(C(=O)O)cn2)c1 to produce CCOc1cccc(-c2ccc(C(=O)NCc3ccc4[nH]c(C(F)(F)F)cc4c3)cn2)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O, CCN(C(C)C)C(C)C |
Using NCC(=O)O, CCOC(=O)c1nc(C#N)c2c(c(Cl)cn2Cc2ccccc2F)c1OC(C)=O to produce N#Cc1nc(C(=O)NCC(=O)O)c(O)c2c(Cl)cn(Cc3ccccc3F)c12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using NCC(=O)O, CCOC(=O)c1nc(C#N)c2c(c(Cl)cn2Cc2ccccc2F)c1OC(C)=O to produce N#Cc1nc(C(=O)NCC(=O)O)c(O)c2c(Cl)cn(Cc3ccccc3F)c12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using O=C1CCN(c2ccc(Br)cc2)CC1 to produce OC1CCN(c2ccc(Br)cc2)CC1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCO |
Using O=C1CCN(c2ccc(Br)cc2)CC1 to produce OC1CCN(c2ccc(Br)cc2)CC1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCO |
Using CC(C)CCn1c(Cn2c(=O)n(C(C)C)c3ccccc32)nc2c(CCl)cccc21, [C-]#N to produce CC(C)CCn1c(Cn2c(=O)n(C(C)C)c3ccccc32)nc2c(CC#N)cccc21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CS(C)=O |
Using CC(C)CCn1c(Cn2c(=O)n(C(C)C)c3ccccc32)nc2c(CCl)cccc21, [C-]#N to produce CC(C)CCn1c(Cn2c(=O)n(C(C)C)c3ccccc32)nc2c(CC#N)cccc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CS(C)=O |
Using COc1ncc(S(C)(=O)=O)cc1CN1CCC(CCc2ccccc2OCC2CCCCC2)CC1 to produce CS(=O)(=O)c1c[nH]c(=O)c(CN2CCC(CCc3ccccc3OCC3CCCCC3)CC2)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O=S(Cl)Cl, CCO |
Using COc1ncc(S(C)(=O)=O)cc1CN1CCC(CCc2ccccc2OCC2CCCCC2)CC1 to produce CS(=O)(=O)c1c[nH]c(=O)c(CN2CCC(CCc3ccccc3OCC3CCCCC3)CC2)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O=S(Cl)Cl, CCO |
Using O=C([O-])[O-], CC(C)(C)c1ccc(CN(CCc2ccc(F)cc2)C(=O)c2cccc3cc[nH]c23)c(O)c1 to produce COc1cc(C(C)(C)C)ccc1CN(CCc1ccc(F)cc1)C(=O)c1cccc2cc[nH]c12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC#N, CI |
Using O=C([O-])[O-], CC(C)(C)c1ccc(CN(CCc2ccc(F)cc2)C(=O)c2cccc3cc[nH]c23)c(O)c1 to produce COc1cc(C(C)(C)C)ccc1CN(CCc1ccc(F)cc1)C(=O)c1cccc2cc[nH]c12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC#N, CI |
Using COc1ccc(-c2c(-c3ccccc3)oc3ncnc(NCCCOCCC#N)c23)cc1, C[Si](C)(C)N=[N+]=[N-] to produce COc1ccc(-c2c(-c3ccccc3)oc3ncnc(NCCCOCCc4nnn[nH]4)c23)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | Cc1ccccc1 |
Using COc1ccc(-c2c(-c3ccccc3)oc3ncnc(NCCCOCCC#N)c23)cc1, C[Si](C)(C)N=[N+]=[N-] to produce COc1ccc(-c2c(-c3ccccc3)oc3ncnc(NCCCOCCc4nnn[nH]4)c23)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | Cc1ccccc1 |
Using CC(C)N(C(=O)n1nnc(-c2c(F)cccc2F)c1C#N)c1cccc(C(=O)OCc2ccccc2)c1 to produce CC(C)N(C(=O)n1nnc(-c2c(F)cccc2F)c1C#N)c1cccc(C(=O)O)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using CC(C)N(C(=O)n1nnc(-c2c(F)cccc2F)c1C#N)c1cccc(C(=O)OCc2ccccc2)c1 to produce CC(C)N(C(=O)n1nnc(-c2c(F)cccc2F)c1C#N)c1cccc(C(=O)O)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CO |
Using Oc1ccc2ccccc2c1, ClCCCBr to produce ClCCCOc1ccc2ccccc2c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(C)=O |
Using Oc1ccc2ccccc2c1, ClCCCBr to produce ClCCCOc1ccc2ccccc2c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(C)=O |
Using O=C1CCOCC1, CC(C)(C)c1cc(NC(=O)[C@@H]2CCN2)on1 to produce CC(C)(C)c1cc(NC(=O)[C@@H]2CCN2C2CCOCC2)on1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(=O)O, CN(C)C=O |
Using O=C1CCOCC1, CC(C)(C)c1cc(NC(=O)[C@@H]2CCN2)on1 to produce CC(C)(C)c1cc(NC(=O)[C@@H]2CCN2C2CCOCC2)on1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CC(=O)O, CN(C)C=O |
Using COC(=O)C1CCC(OC[C@@H]2CC(F)(F)CN2C(=O)Cc2cc(Cl)c(NC(=O)c3cn(C)c4ccccc34)cc2F)CC1 to produce Cn1cc(C(=O)Nc2cc(F)c(CC(=O)N3CC(F)(F)C[C@H]3CO[C@H]3CC[C@H](C(=O)O)CC3)cc2Cl)c2ccccc21, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | C1CCOC1 |
Using COC(=O)C1CCC(OC[C@@H]2CC(F)(F)CN2C(=O)Cc2cc(Cl)c(NC(=O)c3cn(C)c4ccccc34)cc2F)CC1 to produce Cn1cc(C(=O)Nc2cc(F)c(CC(=O)N3CC(F)(F)C[C@H]3CO[C@H]3CC[C@H](C(=O)O)CC3)cc2Cl)c2ccccc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | C1CCOC1 |
Using COC(=O)[C@@H](CC=CCOCc1ccccc1)C[C@@H](OC)c1ccc(F)cc1 to produce COC(=O)[C@@H](CCCCO)C[C@@H](OC)c1ccc(F)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCO |
Using COC(=O)[C@@H](CC=CCOCc1ccccc1)C[C@@H](OC)c1ccc(F)cc1 to produce COC(=O)[C@@H](CCCCO)C[C@@H](OC)c1ccc(F)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCO |
Using CCOC(=O)c1cc(O)cc(OCc2nc3ccccc3c(OCc3ccccc3)c2C)c1, BrCC1CCOCC1 to produce CCOC(=O)c1cc(OCc2nc3ccccc3c(OCc3ccccc3)c2C)cc(OCC2CCOCC2)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O |
Using CCOC(=O)c1cc(O)cc(OCc2nc3ccccc3c(OCc3ccccc3)c2C)c1, BrCC1CCOCC1 to produce CCOC(=O)c1cc(OCc2nc3ccccc3c(OCc3ccccc3)c2C)cc(OCC2CCOCC2)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CN(C)C=O |
Using CCc1cn(S(=O)(=O)c2ccccc2)c2ncnc(N3CCC(NC(=O)c4ccccc4)CC3)c12 to produce CCc1cnc2[nH]cnc(N3CCC(NC(=O)c4ccccc4)CC3)c1-2, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | C1CCOC1, CO |
Using CCc1cn(S(=O)(=O)c2ccccc2)c2ncnc(N3CCC(NC(=O)c4ccccc4)CC3)c12 to produce CCc1cnc2[nH]cnc(N3CCC(NC(=O)c4ccccc4)CC3)c1-2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | C1CCOC1, CO |
Using CCOC(=O)c1c(C(C)C)nc2ccc(Cl)cc2c1Cc1ccccc1OC to produce COc1ccccc1Cc1c(C(=O)O)c(C(C)C)nc2ccc(Cl)cc12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | c1ccncc1 |
Using CCOC(=O)c1c(C(C)C)nc2ccc(Cl)cc2c1Cc1ccccc1OC to produce COc1ccccc1Cc1c(C(=O)O)c(C(C)C)nc2ccc(Cl)cc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | c1ccncc1 |
Using CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-] to produce CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1N, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O |
Using CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-] to produce CC(C)(C)OC(=O)Nc1cc(Cl)c(C(F)(F)F)cc1N, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | O |
Using CCOC(=O)C(CC(OC)OC)C(=O)OCC to produce COC(=O)CCC(OC)OC, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCO |
Using CCOC(=O)C(CC(OC)OC)C(=O)OCC to produce COC(=O)CCC(OC)OC, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format. | CCO |
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