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Using CN, COc1ccc(-c2ccc(C=O)cc2)cc1Br to produce C/N=C/c1ccc(-c2ccc(OC)c(Br)c2)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO", "ClCCl"], "agent": ["[Mg+2]", "O=S(=O)([O-])[O-]"]} |
Using CCOC(=O)C=Cc1cccc([N+](=O)[O-])c1 to produce CCOC(=O)CCc1cccc(N)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CO"], "agent": ["[Pd]"]} |
Using Cc1ccc(Cl)cc1C1CC(=O)CC(=O)C1, [NH4+] to produce Cc1ccc(Cl)cc1C1CC(=O)C=C(N)C1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["CC(=O)[O-]"]} |
Using C=C[Sn](CCCC)(CCCC)CCCC, CCCCCCCc1c(C)nc(C)c(I)c1OC(=O)OC(C)(C)C to produce C=Cc1c(C)nc(C)c(CCCCCCC)c1OC(=O)OC(C)(C)C, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1COCCO1", "ClC(Cl)Cl"], "agent": ["[Cl-]", "[Li+]", "c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using CCBr, CN(CCO)c1ccccc1 to produce CCOCCN(C)c1ccccc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "CS(C)=O"], "agent": ["[K+]", "[OH-]"]} |
Using CI, COCCn1cccc1C(O)(c1ccc(N(C)S(=O)(=O)c2ccccc2)cc1)C(F)(F)F to produce COCCn1cccc1C(OC)(c1ccc(N(C)S(=O)(=O)c2ccccc2)cc1)C(F)(F)F, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using CCOC(C)=O, Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CI to produce CCOC(=O)CCc1sc(-c2ccc(C(F)(F)F)cc2)nc1C, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN1CCCN(C)C1=O", "C1CCOC1"], "agent": ["CC(C)[N-]C(C)C", "[Li+]"]} |
Using CCN(c1cc(Br)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1, Cc1ccc(B(O)O)cc1 to produce CCN(c1cc(-c2ccc(C)cc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1COCCO1", "O"], "agent": ["O=C([O-])[O-]", "[Na+]", "c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using O=C(O)CCCCCCC1=C(C=Cc2ccccc2)C(O)CC1=O, [O-][I+3]([O-])([O-])[O-] to produce O=CC1=C(CCCCCCC(=O)O)C(=O)CC1O, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1COCCO1", "O"], "agent": ["O=[Os](=O)(=O)=O", "[Na+]"]} |
Using CCCOC(OCCC)P(=O)(CCC#N)OCC to produce CCCOC(OCCC)P(=O)(CCCN)OCC, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["N", "[Ni]"]} |
Using CC(=O)NC(C)(C)c1ccc(C(F)(F)F)cc1 to produce CC(C)(N)c1ccc(C(F)(F)F)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOCC", "OCCO"], "agent": ["[K+]", "Cl", "[OH-]"]} |
Using CC(C)c1cccc(NC(=O)c2cccc(N3CCc4c(cncc4C(=O)O)C3)c2)c1, NCCCN1CCOCC1 to produce CC(C)c1cccc(NC(=O)c2cccc(N3CCc4c(cncc4C(=O)NCCCN4CCOCC4)C3)c2)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCCl", "CCN(CC)CC"], "agent": ["CCCP(=O)=O", "CN(C)c1ccncc1"]} |
Using CCOC(=O)CC(c1cc(OCc2cnc(-c3cc(OC)ccc3F)c(O)c2)ncn1)C1CC1, CC(C)(C)CBr to produce CCOC(=O)CC(c1cc(OCc2cnc(-c3cc(OC)ccc3F)c(OCC(C)(C)C)c2)ncn1)C1CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O", "O"], "agent": ["O=C([O-])[O-]", "[Cs+]"]} |
Using OB(O)c1ccc(Oc2ccccc2)cc1, CC(C)(C)OC(=O)N1CCCC(n2nc(I)c3c(N)ncnc32)C1 to produce CC(C)(C)OC(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1COCCO1", "O"], "agent": ["O=C([O-])[O-]", "[Na+]", "c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using CC(C)[C@@H](C)N, CCN(CC)CCCNc1nc(-c2cc(C(=O)O)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1 to produce CCN(CC)CCCNc1nc(-c2cc(C(=O)N[C@H](C)C(C)C)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O", "CCN(CC)CC"], "agent": ["F[P-](F)(F)(F)(F)F", "CN(C)C(On1nnc2ccccc21)=[N+](C)C"]} |
Using COc1cc(CCc2cc(N)n(C(=O)OC(C)(C)C)n2)cc(OC)c1, COC(=O)c1ccc(N2CCN(C(C)=O)CC2)cc1 to produce COc1cc(CCc2cc(NC(=O)c3ccc(N4CCN(C(C)=O)CC4)cc3)n[nH]2)cc(OC)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["C[Si](C)(C)[N-][Si](C)(C)C", "[Na+]"]} |
Using CC(C)(C)OC(=O)c1ccc(-n2c3ccccc3c3c(-c4ccc(C#N)nc4)cccc32)cc1F, NCCCO to produce CC(C)(C)OC(=O)c1ccc(-n2c3ccccc3c3c(-c4ccc(C#N)nc4)cccc32)cc1NCCCO, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "CS(C)=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using c1ccc(-c2cccc3[nH]ccc23)cc1 to produce c1ccc(-c2cccc3c2CCN3)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOC(C)=O", "O=C(O)C(F)(F)F"], "agent": ["[BH3-]C#N", "[Na+]", "[OH-]"]} |
Using C[C@@H](N)c1ccc(Br)cc1, CCOc1ccc(Cl)cc1B(O)O to produce CCOc1ccc(Cl)cc1-c1ccc([C@@H](C)N)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "ClCCl"], "agent": ["CC(=O)[O-]", "[Pd+2]"]} |
Using CC(C)(C)OC(=O)N1CC(=O)C1, C1CCOC1 to produce CC1(O)CN(C(=O)OC(C)(C)C)C1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOC(C)=O", "O"], "agent": ["C[Mg]Br"]} |
Using OB(O)c1ccncc1, O=Cc1ccc2c(c1)N(Cc1cccc(I)c1)C(=O)CO2 to produce O=Cc1ccc2c(c1)N(Cc1cccc(-c3ccncc3)c1)C(=O)CO2, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O", "O"], "agent": ["O=C([O-])[O-]", "[Na+]", "c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using CC(C)CN(Cc1ccc2c(c1)C(OC1CCCCO1)CCCC2)C(=O)C1CN(C(=O)OC(C)(C)C)CCO1 to produce CC(C)CN(Cc1ccc2c(c1)C(O)CCCC2)C(=O)C1CN(C(=O)OC(C)(C)C)CCO1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["c1cc[nH+]cc1", "Cc1ccc(S(=O)(=O)[O-])cc1"]} |
Using CC(=O)NC1CCc2cc(SC(C)(C)C(=O)OC(C)(C)C)c(Br)cc2C1, OB(O)c1ccccc1 to produce CC(=O)NC1CCc2cc(SC(C)(C)C(=O)OC(C)(C)C)c(-c3ccccc3)cc2C1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOC(C)=O", "Cc1ccccc1"], "agent": ["O=C([O-])[O-]", "[Na+]", "c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using O=Cc1cnccc1-c1ccc(Cl)cc1F to produce OCc1cnccc1-c1ccc(Cl)cc1F, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1CCOC1", "CO"], "agent": ["[Na+]", "[BH4-]"]} |
Using Cn1ncc([N+](=O)[O-])c1N1CCN(C(=O)OC(C)(C)C)CC(C)(O)C1 to produce Cn1ncc(N)c1N1CCN(C(=O)OC(C)(C)C)CC(C)(O)C1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CO"], "agent": ["[Pd]"]} |
Using COC(=O)c1ccc2nsnc2c1, C1CCNCC1 to produce O=C(c1ccc2nsnc2c1)N1CCCCC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCl"], "agent": ["C[Al](C)C"]} |
Using Nc1ccc(C2(c3ccc(Cl)cc3)OCCO2)cc1C(O)c1cccc(Cl)c1, O=C(Br)CBr to produce O=C(CBr)Nc1ccc(C2(c3ccc(Cl)cc3)OCCO2)cc1C(O)c1cccc(Cl)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCl"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using COc1ccc(C=O)cc1O, ClC1C=CCC1 to produce COc1ccc(C=O)cc1OC1C=CCC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using CC1(C)COC(CCC(=O)c2ccc(F)cc2)OC1, CNS(=O)(=O)c1ccc(N)cc1 to produce CNS(=O)(=O)c1ccc(-n2cccc2-c2ccc(F)cc2)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["Cc1ccccc1"], "agent": ["Cc1ccc(S(=O)(=O)O)cc1"]} |
Using NC(=O)c1ccnc(-c2c[nH]cn2)c1, CCOc1ccccc1CCOS(C)(=O)=O to produce CCOc1ccccc1CCn1cnc(-c2cc(C(N)=O)ccn2)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using CCOC(=O)CC(=O)C(F)(F)F, COc1ccc(N)c(OC)c1 to produce COc1cc(OC)c2nc(C(F)(F)F)cc(O)c2c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "c1ccccc1"], "agent": ["Cc1ccc(S(=O)(=O)O)cc1"]} |
Using CCCC1(C)C(=O)N(Cc2ccccc2)S(=O)(=O)N1C to produce CCCC1(C)C(=O)NS(=O)(=O)N1C, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CO"], "agent": ["O=C[O-]", "[NH4+]", "[Pd]"]} |
Using O=C1CCC2(CC1)CCC(=O)c1ccccc12 to produce O=C1CCC2(CCCc3ccccc32)CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "OCCO"], "agent": ["[K+]", "NN", "[OH-]"]} |
Using CC(=O)Nc1ccc2[nH]c(C(=O)N3CC(CCl)c4c3cc([N+](=O)[O-])c3ccccc43)cc2c1 to produce CC(=O)Nc1ccc2[nH]c(C(=O)N3CC(CCl)c4c3cc(N)c3ccccc43)cc2c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["O=[Pt]=O"]} |
Using CC(=O)OC(C)=O, CC(C(O)c1ccccc1)[N+](=O)[O-] to produce CC(=O)OC(c1ccccc1)C(C)[N+](=O)[O-], please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOCC", "CO"], "agent": ["CN(C)c1ccncc1"]} |
Using COc1ccc(Nc2ncnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)cc23)cn1 to produce O=c1ccc(Nc2ncnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)cc23)c[nH]1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOC(C)=O", "ClC(Cl)Cl"], "agent": ["[Na+]", "O=C([O-])O"]} |
Using CC(=O)c1ccc(Oc2ccc([N+](=O)[O-])cn2)cc1, OCCO to produce CC1(c2ccc(Oc3ccc([N+](=O)[O-])cn3)cc2)OCCO1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["c1ccccc1"], "agent": ["CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2"]} |
Using CC(C)(C)OC(=O)Nc1cc(-c2cccc(O)c2)ccc1Cl to produce Nc1cc(-c2cccc(O)c2)ccc1Cl, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CC(C)O"], "agent": ["Cl"]} |
Using CCOC(=O)Cl, NCCCCC(=O)O to produce COC(=O)NCCCCC(=O)O, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1COCCO1", "O"], "agent": ["O=C([O-])[O-]", "[K+]", "Cl"]} |
Using COc1cc(C2CN(C(=O)c3cc(O)ccn3)C2)ccc1OCc1ccc(C2CC2)cc1, Cc1ccc(S(=O)(=O)OC[C@H]2COC(C)(C)O2)cc1 to produce COc1cc(C2CN(C(=O)c3cc(OC[C@H]4COC(C)(C)O4)ccn3)C2)ccc1OCc1ccc(C2CC2)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O", "O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using COC(=O)Nc1ccc(NCC2CC2)c(N)c1, CCOc1ccc(CC(=O)O)cc1 to produce CCOc1ccc(Cc2nc3cc(NC(=O)OC)ccc3n2CC2CC2)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCN(C(C)C)C(C)C"], "agent": ["F[P-](F)(F)(F)(F)F", "CN(C)C(On1nnc2cccnc21)=[N+](C)C"]} |
Using Brc1cccc(I)c1, OB(O)c1ccc(-c2ccccc2)c2ccccc12 to produce Brc1cccc(-c2ccc(-c3ccccc3)c3ccccc23)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["Cc1ccccc1", "COCCOC"], "agent": ["O=C([O-])[O-]", "[Na+]", "c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using CC(=O)O, Cc1ccc2nc(Cl)nc(Cl)c2c1 to produce Cc1ccc2nc(Cl)[nH]c(=O)c2c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Na+]", "[OH-]"]} |
Using COc1cc(C(N)=O)ccc1OCCCBr, Fc1ccc2c(C3CCNCC3)noc2c1 to produce COc1cc(C(N)=O)ccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CC#N"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCN(c2nc(C)cc(C(=O)OC)n2)C3)cc1 to produce CCNC(=O)Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CCN(c2nc(C)cc(C(=O)O)n2)C3)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CO"], "agent": ["[Na+]", "Cl", "[OH-]"]} |
Using C=CCN(CC(=O)OCC)NC(=O)NCc1ccccc1 to produce CN(CC(=O)O)NC(=O)NCc1ccccc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O"], "agent": ["[Li+]", "[OH-]"]} |
Using COc1cc2cc3ncc(C#N)c(Nc4ccc(Cl)cc4Cl)c3cc2cc1OC to produce N#Cc1cnc2cc3cc(O)c(O)cc3cc2c1Nc1ccc(Cl)cc1Cl, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["c1ccncc1"], "agent": ["[NH4+]", "Cl", "[OH-]"]} |
Using C1COCCO1, O=C(O)CCc1ccc(Br)cc1 to produce COC(=O)CCc1ccc(Br)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CO"], "agent": ["Cl"]} |
Using CC(=O)OC(C)=O, Nc1cccc(Br)c1 to produce CC(=O)Nc1cccc(Br)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCl", "CCN(CC)CC"], "agent": ["CN(C)c1ccncc1"]} |
Using COc1ccc2c(c1)CC(C#N)CO2 to produce COc1ccc2c(c1)CC(CN)CO2, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOCC"], "agent": ["[Al+3]", "[Li+]", "[H-]"]} |
Using CI, O=C1[C@H](Cc2c(Cl)cc(OCc3ccccc3)cc2Cl)CCN1[C@H]1CC[C@H](O)CC1 to produce CO[C@H]1CC[C@H](N2CC[C@@H](Cc3c(Cl)cc(OCc4ccccc4)cc3Cl)C2=O)CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using CCOC(=O)c1c(-c2ccc(O)nc2)nc(-c2ccc(OC(F)(F)F)cc2)n1C1CC1 to produce O=C(O)c1c(-c2ccc(O)nc2)nc(-c2ccc(OC(F)(F)F)cc2)n1C1CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["[Na+]", "[OH-]"]} |
Using O=c1[nH]c2cc(F)c(F)cc2c(=O)n1OCc1ccccc1, BrCC1CC1 to produce O=c1c2cc(F)c(F)cc2n(CC2CC2)c(=O)n1OCc1ccccc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using CC(C)[Si](Cl)(C(C)C)C(C)C, OCc1nnc(Br)s1 to produce CC(C)[Si](OCc1nnc(Br)s1)(C(C)C)C(C)C, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOC(C)=O", "CN(C)C=O"], "agent": ["c1c[nH]cn1"]} |
Using OC(c1ccc(Cl)cc1)c1ccccc1OCc1ccccc1 to produce Clc1ccc(Cc2ccccc2OCc2ccccc2)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CC#N", "O"], "agent": ["CC[SiH](CC)CC"]} |
Using Cc1cc2c(cc1C)C(=O)C(CN(C)C)CC2, O=C1NCN(c2ccccc2)C12CCNCC2 to produce Cc1cc2c(cc1C)C(=O)C(CN1CCC3(CC1)C(=O)NCN3c1ccccc1)CC2, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["Cl"]} |
Using CCCCOC(C)c1cn(S(=O)(=O)c2ccc(C)cc2)c2nc(Nc3ccc4cn[nH]c4c3)nc(NC3CC3)c12 to produce CCCCOC(C)c1c[nH]c2nc(Nc3ccc4cn[nH]c4c3)nc(NC3CC3)c12, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1COCCO1"], "agent": ["[K+]", "[OH-]"]} |
Using C=C(CBr)C(=O)OCC, CS to produce C=C(CSC)C(=O)OCC, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO", "O"], "agent": ["[Na]"]} |
Using O=Cc1ccc(Cl)cc1O, C=CS(=O)(=O)N1CCN(CC2CCN(C(=O)OC(C)(C)C)CC2)C(=O)C1 to produce CC(C)(C)OC(=O)N1CCC(CN2CCN(S(=O)(=O)C3=Cc4ccc(Cl)cc4OC3)CC2=O)CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CC(C)(C)O"], "agent": ["CC(C)(C)[O-]", "[K+]"]} |
Using CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@H]21 to produce CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C21, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["O=C1CCC(=O)N1O", "C(=NC1CCCCC1)=NC1CCCCC1"]} |
Using CCCC(=O)c1ccc(OCCCCC(=O)O)c(Cl)c1Cl, CNC to produce C=C(CC)C(=O)c1ccc(OCCCCC(=O)O)c(Cl)c1Cl, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O", "CC(=O)O"], "agent": ["Cl", "C=O"]} |
Using O=CCCl, Nc1cccc(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1Cl to produce O=C(NCC12CC3CC(CC(C3)C1)C2)c1cccc(NCCCl)c1Cl, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "CO"], "agent": ["[BH3-]C#N", "[Na+]", "Cl"]} |
Using CCCn1ccnc1CCl, CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(O)cc2)CCN3CC(C)C)cc1 to produce CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(OCc4nccn4CCC)cc2)CCN3CC(C)C)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[K+]", "Cl"]} |
Using BrCCCCCCCCCCCBr, Oc1ccc(C2CCC(O)CC2)cc1 to produce OC1CCC(c2ccc(OCCCCCCCCCCCBr)cc2)CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCC(C)=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using C[C@H](NS(=O)(=O)c1ccccc1[N+](=O)[O-])C(=O)N1CCC[C@H]1C(=O)O to produce C[C@H](NS(=O)(=O)c1ccccc1N)C(=O)N1CCC[C@H]1C(=O)O, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["[H][H]", "[C]", "[Pd]"]} |
Using CC(C)[N-]C(C)C, COc1cc(C(F)(F)F)ccc1C1=NC(C)(C)CO1 to produce COc1c(C2=NC(C)(C)CO2)ccc(C(F)(F)F)c1C, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CI", "C1CCOC1"], "agent": ["[Li+]"]} |
Using COc1cc([N+](=O)[O-])ccc1-n1cnc(CO)c1 to produce COc1cc(N)ccc1-n1cnc(CO)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOC(C)=O", "CO"], "agent": ["[Na+]", "O=C([O-])O"]} |
Using CCO, CC(C)(C)N1C(=O)CC(c2ccc(C(Br)Br)cc2F)S1(=O)=O to produce CC(C)(C)N1C(=O)CC(c2ccc(C=O)cc2F)S1(=O)=O, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O"], "agent": ["O=[N+]([O-])[O-]", "[Ag+]"]} |
Using CCCC(=O)NC[C@@H]1C[C@H]1c1cccc(OC)c1, CCCC(=O)NC[C@@H]1C[C@H]1c1cccc(O)c1 to produce C=CCOc1cccc([C@@H]2C[C@H]2CNC(=O)CCC)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCl"], "agent": ["BrB(Br)Br"]} |
Using C=C1CCC2CC1C2(C)C, O=S([O-])O to produce CC(C)[C@@H]1CC=C(CS(=O)(=O)[O-])CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "CC(C)O"], "agent": ["[NH4+]"]} |
Using CC(=O)OCCCN1CCC(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC1 to produce CC(=O)OCCCN1CCC(CO)CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[F-]", "CCCC[N+](CCCC)(CCCC)CCCC"]} |
Using O=C1NC(=O)C(c2cn3c4c(cccc24)CCC3)=C1c1c[nH]c2ccccc12 to produce O=C1NC(=O)[C@@H](c2cn3c4c(cccc24)CCC3)[C@@H]1c1c[nH]c2ccccc12, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCOC(C)=O", "CO"], "agent": ["[Mg]"]} |
Using CN1CCCC1CO, O=[N+]([O-])c1cncc([N+](=O)[O-])c1 to produce CN1CCC[C@H]1COc1cncc([N+](=O)[O-])c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O", "O"], "agent": ["[Cl-]", "[Na+]", "[H-]"]} |
Using C=Cc1ccc(OC(C)=O)cc1 to produce C=Cc1ccc(O)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O"], "agent": ["[K+]", "[OH-]"]} |
Using Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1, CNC(=N)NC#N to produce CNC(=N)NC(=N)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O"], "agent": ["Cl"]} |
Using CN(C)CCCN, O=C(CC1CSCCC1=O)c1ccccc1 to produce CN(C)CCCn1c(-c2ccccc2)cc2c1CCSC2, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO", "CCOCC"], "agent": ["Cl"]} |
Using N=C(N)c1ccc2cc(OC(=O)c3ccc(CN)o3)ccc2c1, O=C1CCCC(=O)O1 to produce N=C(N)c1ccc2cc(OC(=O)c3ccc(CNC(=O)CCCC(=O)O)o3)ccc2c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["CC(=O)[O-]", "[Na+]", "Cl"]} |
Using BrCc1ccccc1, OCC1CCCC(O)C1 to produce OC1CCCC(COCc2ccccc2)C1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCCCCC", "CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using O=S(=O)(O)c1ccc(OCc2ccccc2)cc1, O=C(Cl)C(=O)Cl to produce O=S(=O)(Cl)c1ccc(OCc2ccccc2)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O", "ClCCl"], "agent": ["[Na]"]} |
Using COc1ccc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)cc1 to produce Cn1c(C(F)(F)F)cc(=O)n(-c2ccc(O)cc2)c1=O, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCl"], "agent": ["BrB(Br)Br"]} |
Using NC1CC1, C[C@H]1CN(Cc2ccccc2)C[C@@H]1C(=O)O to produce C[C@H]1CN(Cc2ccccc2)C[C@@H]1C(=O)NC1CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCl"], "agent": ["CCN=C=NCCCN(C)C", "Cl"]} |
Using Nc1cc(O)cc(Cl)c1NC(=O)C1CCOC1 to produce Oc1cc(Cl)c2[nH]c(C3CCOC3)nc2c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "CO"], "agent": ["Cc1ccc(S(=O)(=O)O)cc1"]} |
Using O[C@H]1CN[C@H](CNC2CC2)C1, Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)O to produce Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1C[C@H](O)C[C@H]1CNC1CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O", "ClCCCl"], "agent": ["On1nnc2ccccc21"]} |
Using COCC(=O)O, CC(C)(C)OC(=O)N(C[C@@H]1CCc2cc(-c3cccc(S(N)(=O)=O)c3)ccc2O1)C[C@H](O[Si](C)(C)C(C)(C)C)c1cccnc1 to produce COCC(=O)NS(=O)(=O)c1cccc(-c2ccc3c(c2)CC[C@@H](CN(C[C@H](O[Si](C)(C)C(C)(C)C)c2cccnc2)C(=O)OC(C)(C)C)O3)c1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCl"], "agent": ["CCN=C=NCCCN(C)C", "CN(C)c1ccncc1"]} |
Using O=c1oc(=O)n(Cc2ccccc2)c2ncccc12, CCOC(=O)CC(=O)OCC to produce CCOC(=O)c1c(O)c2cccnc2n(Cc2ccccc2)c1=O, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CC(=O)N(C)C"], "agent": ["[Na+]", "Cl", "[H-]"]} |
Using CCCCCCCCCCS, Cc1ccc(Sc2c(Cl)c(C(=O)O)c(C(O)=NCCO)c(Cl)c2Sc2ccc(C)cc2)cc1 to produce CCCCCCCCCCSc1c(Sc2ccc(C)cc2)c(Sc2ccc(C)cc2)c(SCCCCCCCCCC)c(C(O)=NCCO)c1C(=O)O, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using CC(C)[Si](Cl)(C(C)C)C(C)C, Brc1cnc2[nH]ccc2c1 to produce CC(C)[Si](C(C)C)(C(C)C)n1ccc2cc(Br)cnc21, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using C[N+]1([O-])CCOCC1, C=CCc1c(Cl)ncnc1-c1ccccn1 to produce O=CCc1c(Cl)ncnc1-c1ccccn1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1COCCO1"], "agent": ["O=[Os](=O)(=O)=O"]} |
Using O=C(O)c1ccc(OCCCCCCc2cccc(OCc3ccccc3)c2OCc2ccccc2)c(Cl)c1 to produce O=C(O)c1ccccc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[H][H]", "[Pd]"]} |
Using O=Cc1ccc(B(O)O)cc1, COc1ccc(C(c2ccc(OC)cc2)(c2ccc(OC)cc2)n2cc(Br)cn2)cc1 to produce COc1ccc(C(c2ccc(OC)cc2)(c2ccc(OC)cc2)n2cc(-c3ccc(C=O)cc3)cn2)cc1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "COCCOC"], "agent": ["O=C([O-])[O-]", "[K+]", "c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccnc21 to produce Cn1ncc2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccnc21, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["O=S(=O)(O)O", "O=N[O-]", "[Na+]"]} |
Using CCOC(=O)C(C)P(=O)(OCC)OCC, O=Cc1cn(-c2cccnc2)c2ccccc12 to produce CCOC(=O)C(C)=Cc1cn(-c2cccnc2)c2ccccc12, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["CC(C)[N-]C(C)C", "[Li+]"]} |
Using CC(C)(CSC#N)CS(N)(=O)=O to produce CC(C)(CS)CS(N)(=O)=O, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["[Na+]", "[BH4-]"]} |
Using CC(C)(C)CC1NC(C(=O)O)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F, NC(=O)c1cccc(N)c1 to produce CC(C)(C)CC1NC(C(=O)Nc2cccc(C(N)=O)c2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCl", "CCN(C(C)C)C(C)C"], "agent": ["F[P-](F)(F)(F)(F)F", "CN(C)C(On1nnc2cccnc21)=[N+](C)C"]} |
Using Sc1nc2ccccc2[nH]1, CN(C)c1ccccc1CCl to produce CN(C)c1ccccc1CSc1nc2ccccc2[nH]1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["Cl"]} |
Using COc1ccccc1N1CCNCC1, Nc1cc(Cl)ccc1[N+](=O)[O-] to produce COc1ccccc1N1CCN(c2ccc([N+](=O)[O-])c(N)c2)CC1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["O", "CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[K+]", "Cl"]} |
Using O=C1CN(c2ccc(S(=O)(=O)c3ccccc3)cc2OCc2ccccc2)S(=O)(=O)N1 to produce O=C1CN(c2ccc(S(=O)(=O)c3ccccc3)cc2O)S(=O)(=O)N1, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["ClCCl"], "agent": ["[K]", "BrB(Br)Br"]} |
Using COc1ccc(CC#N)cc1OC to produce COc1ccc(CCN)cc1OC, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CCO"], "agent": ["[Ni]", "N"]} |
Using O=C(O)CCCCCCCBr, C[S-] to produce CSCCCCCCCC(=O)O, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["CO"], "agent": ["[Na+]"]} |
Using COC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(c3ccc(Cl)cc3F)[C@H]2c2cccc(Br)c2)cc1 to produce CC(C)(C)C[C@@H]1N[C@@H](C(=O)Nc2ccc(C(=O)O)cc2)[C@H](c2cccc(Br)c2)[C@@]1(C#N)c1ccc(Cl)cc1F, please predict the condition, including solvent and agent in SMILES notation in json format like:
```json
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": ["[Na+]", "[H-]"]
}
```
| {"solvent": ["C1CCOC1", "CO"], "agent": ["[Na+]", "Cl", "[OH-]"]} |
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